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Our sensitivity analysis with exenatide suggests that NAION may be unique to semaglutide, indicating a mechanism beyond transient glucose reductions associated with GLP-1 RAs. The growing compendium of research exposing the ocular risks associated with GLP-1 RAs is concerning as the popularity of these drugs continues to rise, though more prospective studies are still needed to clarify the mechanisms behind these associations
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Following this discovery, pharmaceutical companies developed a formulation of tirzepatide specifically for weight loss, distributing the drug under the trade name Zepbound
[44] Brass EP.Ann N Y Acad Sci
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